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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T28722	SCH 57790 SCH57790,SCH-57790	AChR	Neuroscience
	SCH 57790 是一种新型且具有选择性的毒蕈碱 M（2）受体拮抗剂，可释放乙酰胆碱并增强实验动物的认知能力，可用于治疗阿尔茨海默病。
T26373	(R)-Mequitazine V-0162,V0162,V 0162
	(R)-Mequitazine, a muscarinic acetylcholine receptor (M-AChRs) antagonist, is used potentially for the treatment of asthma.
T69336	NNC-11-1585
	NNC-11-1585 is an M(1) and M(2) muscarinic acetylcholine receptor (mAChR) agonist.
T26770	Bencycloquidium Bromide BCQB
	Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M
T74708	β2AR/M-receptor agonist-1
	β2AR/M-receptor agonist-1 (example 131) 为一种结合β2 肾上腺素能受体激动剂功能与毒蕈碱拮抗剂属性的MABA。其对β2 肾上腺素能受体的EC50 值为9.2 nM，对毒蕈碱受体的Ki 值为30.2 nM，展现出强大的MABA效能，EC50值仅为4.0 nM。
T72226	β2AR/M-receptor agonist-2
	β2AR/M-receptor agonist-2 是毒蕈碱拮抗剂和β2 肾上腺素受体激动剂 (MABA)。β2AR/M-receptor agonist-2 对 β2 肾上腺素受体的EC50值为 3.7 nM。β2AR/M-receptor agonist-2 对人 M3 受体的Ki 值为 0.73 nM。β2AR/M-receptor agonist-2 是一种有效的支气管扩张剂，可用于慢性阻塞性肺疾病 (COPD) 的研究。
T37728	Methoctramine (hydrate)
	Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit...
T36241	Arecaidine propargyl ester (hydrobromide)
	Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai...

化合物

SCH 57790

Cat.No: T28722

Synonym: SCH57790,SCH-57790

Target: AChR

(R)-Mequitazine

Cat.No: T26373

Synonym: V-0162,V0162,V 0162

Bencycloquidium Bromide

Cat.No: T26770

Synonym: BCQB

Target:

β2AR/M-receptor agonist-1

Cat.No: T74708

Synonym:

Target:

β2AR/M-receptor agonist-2

Cat.No: T72226

Synonym:

Target:

Methoctramine (hydrate)

Cat.No: T37728

Synonym:

Target:

Arecaidine propargyl ester (hydrobromide)

Cat.No: T36241

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。